Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to My Articles & Searches Download to citation manager Citing Articles via HighWire Citing Articles via Google Scholar Articles by Owens, D. C. Search for Related Content PubMed Citation Articles by Owens, D. C. Quality of Care, Practice Guidelines Atypical Neuroleptics Conventional Neuroleptics Research Design, Methodology Schizophrenia Spectrum Disorders Related Articles

What CATIE Did: Some Thoughts on Implications Deep and Wide

The author discusses five lessons that can be learned from the seminal results of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE). The lessons extend beyond practice implications to fundamental questions about how psychopharmacology studies are conducted and how results are interpreted and given relevance in regard to prescribing. The author recounts the history of the term "atypical" and how it came to be understood in the context of antipsychotics. The error of using high-dose haloperidol as a comparator in assessments of new antipsychotics—and of generalizing from the results of these studies—is also discussed. The CATIE results force uncomfortable questions about the extent of knowledge concerning the clinical pharmacology of a major treatment modality, which the author illustrates by examining possible reasons for the differential clinical actions of clozapine. The author concludes that CATIE benefited both patients and clinicians by opening up to patients the full gamut of antipsychotics for treatment planning and by reinstating to physicians their key skill in expert, individualized prescribing.

Related Articles:

May 2008: This Month's Highlights
Psychiatr Serv 2008 59: 475. [Full Text] [PDF]

This article has been cited by other articles:

				R. Drake, J. Skinner, and H. H. Goldman What Explains the Diffusion of Treatments for Mental Illness? Am J Psychiatry, November 1, 2008; 165(11): 1385 - 1392. [Full Text] [PDF]

				M. S. Swartz Introduction to the CATIE Special Section Psychiatr Serv, May 1, 2008; 59(5): 497 - 499. [Full Text] [PDF]

Get information about faster international access.

Privacy Policy

Copyright © 2008 American Psychiatric Association. All rights reserved.

Home | Search | Current Issue | Past Issues | Subscribe | All APPI Journals | Help | Contact Us